Solving the difficult problems gives us our greatest satisfaction. For example, how do you accurately dose different drugs, in multiple eye drops, into the eyes of a thrashing two-year-old? As many ophthalmologists and optometrists know, it’s a little like a WWF free-for-all: a tag team of staff to pin the shoulders, hold the head, open the eyes and instill the drops – never knowing how many drops really go in.
The answer came in a solution containing all of the drugs, in a metered-dose applicator that is sprayed on the eyelid, documented (and published) to provide the same effect as the medications painstakingly and individually instilled. Stressed staff, patients and parents are now smiling. Professional Compounding Center of California has provided this customized agent for very long time, containing as many as four medications in a sterile, stabilized, preserved, and pH adjusted spray.
When a disease or condition of the human body demands the care of a specialist, like an ophthalmologist, sometimes the situation warrants the individualized, innovative and flexible drug therapy of Professional Compounding Center of California.
We provide sterile solutions, ointments, suspensions and injections to greatly increase the breadth and depth of drug therapies for the eye care specialist. This frees the practitioner from the limited choices of commercial medications and opens a world of therapeutic possibilities.
Preservative-free? Benzalkonium chloride is found in most commercial preparations at concentrations 100 times the amount shown to be toxic to the corneal endothelium. Other preservatives can be irritating or cause allergic reactions. Many medications, or suitable alternatives, can be prepared preservative-free. Retinologists often prefer a preservative-free intravitreal triamcinolone, which is only available from a sterile-qualified compounding pharmacy.
Higher or lower drug concentration? Long-term therapy, pediatrics, geriatrics, aggressive therapy, and other circumstances can occur where a higher or lower drug concentration would be preferable to a standard commercial product.
Increased viscosity or a multi-drug product, or both? This is inherently important since the eye barely holds even one drop in five to ten minutes. When multiple drops and multiple drugs are prescribed, complexity quickly escalates as drops are instilled too close together, causing a diluting and flushing effect. By incorporating multiple drugs into a single drop and/or increasing viscosity, tissue contact time and effect are therefore enhanced. A multi-drug product can reduce administration time and improve patient compliance.
Although an abundance of antibiotics and antifungals are commercially-available, resistance still occurs. Compounded eye drops like vancomycin, tobramycin, ceftazidime, gentamycin, and cefazolin increase prescribing flexibility for the ophthalmologist. Amphotericin B, clotrimazole, miconazole, fluconazole and polyhexamethyline biguanide provide additional options.
Commercial drugs are often discontinued based on profit and loss, not safety and effectiveness. Dexamethasone, hydroxyamphetamine, idoxuridine, vidarabine and other ophthalmic agents have left the market simply because of sales.
When Wyeth discontinued Wydase® in 2000, many doctors turned to sterile-qualified compounding pharmacies for hyaluronidase, and continue to do so today.
Parameters of sterility, tonicity, pH, preservatives, stability, viscosity and packaging are considered with each compound. In addition, it is best practice for a compounding pharmacy to test every compound for sterility, and have a program in place for testing potency by independent laboratory analysis.
When a condition presents with complexities in drug therapy and a commercial product is less than optimal, a pharmacy specializing in compounded medications may be the answer. Chances are good it will be “problem solved.”
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